Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Phox2a  paired-like homeobox 2a   (Synonyms: Arix, Pmx2, Pmx2a, Px2a)
Results	Reference
1	J:54240 Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM , Rubenstein JL , Ericson J, Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15;398(6728):622-7
1	J:224198 Chen Y, Takano-Maruyama M, Fritzsch B, Gaufo GO, Hoxb1 controls anteroposterior identity of vestibular projection neurons. PLoS One. 2012;7(4):e34762
1	J:166770 Coppola E, d'Autreaux F, Rijli FM, Brunet JF, Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010 Dec;137(24):4211-20
1	J:126634 Coppola E, Pattyn A, Guthrie SC, Goridis C, Studer M, Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation. EMBO J. 2005 Dec 21;24(24):4392-403
1	J:175535 Deng Q, Andersson E, Hedlund E, Alekseenko Z, Coppola E, Panman L, Millonig JH, Brunet JF, Ericson J, Perlmann T, Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408
1	J:98501 Ding YQ, Kim JY, Xu YS, Rao Y, Chen ZF, Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. Development. 2005 May;132(9):2047-56
1	J:92064 Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, Chen ZF, Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development. 2004 Aug;131(15):3693-703
1	J:196818 Espana A, Clotman F, Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Mol Cell Neurosci. 2012 May;50(1):93-102
1	J:86070 Grillet N, Dubreuil V, Dufour HD, Brunet JF, Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b. J Neurosci. 2003 Nov 19;23(33):10613-21
1	J:119188 Hirsch MR, Glover JC, Dufour HD, Brunet JF, Goridis C, Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype. Dev Biol. 2007 Mar 15;303(2):687-702
1*	J:46409 Hirsch MR, Tiveron MC, Guillemot F, Brunet JF, Goridis C, Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development. 1998 Feb;125(4):599-608
1	J:231979 Huettl RE, Eckstein S, Stahl T, Petricca S, Ninkovic J, Gotz M, Huber AB, Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development. Dev Biol. 2016 May 1;413(1):86-103
1	J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1	J:284905 Kabayiza KU, Masgutova G, Harris A, Rucchin V, Jacob B, Clotman F, The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development. Front Mol Neurosci. 2017;10:157
1	J:130846 Kittappa R, Chang WW, Awatramani RB, McKay RD, The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 2007 Dec;5(12):e325
1	J:39084 Morin X, Cremer H, Hirsch MR, Kapur RP, Goridis C, Brunet JF, Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron. 1997 Mar;18(3):411-23
1	J:63723 Pattyn A, Goridis C, Brunet JF, Specification of the central noradrenergic phenotype by the homeobox gene Phox2b. Mol Cell Neurosci. 2000 Mar;15(3):235-43
1*	J:110707 Pattyn A, Guillemot F, Brunet JF, Delays in neuronal differentiation in Mash1/Ascl1 mutants. Dev Biol. 2006 Jul 1;295(1):67-75
1*	J:43772 Pattyn A, Morin X, Cremer H, Goridis C, Brunet JF, Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development. 1997 Oct;124(20):4065-75
1	J:55391 Pattyn A, Morin X, Cremer H, Goridis C, Brunet JF, The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature. 1999 May 27;399(6734):366-70
1	J:72062 Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q, Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev. 2001 Oct 1;15(19):2533-45
1*	J:332883 Rastegar-Pouyani S, Kennedy TE, Kania A, Somatotopy of Mouse Spinothalamic Innervation and the Localization of a Noxious Stimulus Requires Deleted in Colorectal Carcinoma Expression by Phox2a Neurons. J Neurosci. 2022 Oct 19;42(42):7885-7899
1	J:298882 Roome RB, Bourojeni FB, Mona B, Rastegar-Pouyani S, Blain R, Dumouchel A, Salesse C, Thompson WS, Brookbank M, Gitton Y, Tessarollo L, Goulding M, Johnson JE, Kmita M, Chedotal A, Kania A, Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans. Cell Rep. 2020 Nov 24;33(8):108425
1*	J:286599 Song NN, Ma P, Zhang Q, Zhang L, Wang H, Zhang L, Zhu L, He CH, Mao B, Ding YQ, Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199
1*	J:44471 Tiveron MC, Hirsch MR, Brunet JF, The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system. J Neurosci. 1996 Dec 1;16(23):7649-60
1	J:107718 Tiveron MC, Pattyn A, Hirsch MR, Brunet JF, Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus. Dev Biol. 2003 Aug 1;260(1):46-57
1	J:98339 Tsarovina K, Pattyn A, Stubbusch J, Muller F, van der Wees J, Schneider C, Brunet JF, Rohrer H, Essential role of Gata transcription factors in sympathetic neuron development. Development. 2004 Oct;131(19):4775-86
1	J:130853 Wildner H, Gierl MS, Strehle M, Pla P, Birchmeier C, Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development. 2008 Feb;135(3):473-81